Methanol → 2-Chloro-6-methoxypyridin-4-amine

HRID 334054

Reaction equation

HRID 334054 reaction equation
[Na].[Cl:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[C:5](Cl)[N:4]=1.[CH3:11][OH:12]>>[Cl:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[C:5]([O:12][CH3:11])[N:4]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 1376524-Amino-2,6-dichloropyridineHCID 5360545Sodium

Product 1

HCID 713025122-Chloro-6-methoxypyridin-4-amine

Conditions

Temperature
150 °C

Procedure

To a solution of 1.84 g (44.0 mmol) sodium in 40 mL MeOH was added 6.72 g (40.0 mmol) 2,6-dichloro-pyridin-4-ylamine. The reaction mixture was stirred at 150° C. for 30 min under microwave irradiation. The solvent was evaporated and ice water was added. The precipitate was filtered off, washed with water and dried.

Workup

  1. customThe solvent was evaporated
  2. additionice water was added
  3. filtrationThe precipitate was filtered off
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-d4a7b52437e44155b9cd4be82e8585e1
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Linked notes

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