Methanol → 2-Chloro-6-methoxypyridin-4-amine

HRID 334057

Reaction equation

HRID 334057 reaction equation
[Na].[Cl:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[C:5](Cl)[N:4]=1.[CH3:11][OH:12]>>[Cl:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[C:5]([O:12][CH3:11])[N:4]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 1376524-Amino-2,6-dichloropyridineHCID 5360545Sodium

Product 1

HCID 713025122-Chloro-6-methoxypyridin-4-amine

Conditions

Temperature
150 °C

Procedure

To a solution of 1.84 g (44.0 mmol) sodium in 40 mL MeOH was added 6.72 g (40.0 mmol) 2,6-dichloro-pyridin-4-ylamine. The reaction mixture was stirred at 150° C. for 30 min under microwave irradiation. The solvent was evaporated and ice water was added. The precipitate was filtered off, washed with water and dried.

Workup

  1. customThe solvent was evaporated
  2. additionice water was added
  3. filtrationThe precipitate was filtered off
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-6e476dc327cb4e6db5cc1ade55d580b7
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Linked notes

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