Tricalcium Phosphate → Alendronic Acid

HRID 336065

Reaction equation

HRID 336065 reaction equation
P([O-])([O-])([O-])=O.[Ca+2].P([O-])([O-])([O-])=O.[Ca+2].[Ca+2].[CH2:14]([CH2:26][NH2:27])[CH2:15][C:16]([P:22]([O-:25])([OH:24])=[O:23])([P:18]([OH:21])([OH:20])=[O:19])[OH:17].[Na+]>O>[CH2:14]([CH2:26][NH2:27])[CH2:15][C:16]([P:18]([OH:20])([OH:21])=[O:19])([P:22]([OH:25])([OH:24])=[O:23])[OH:17]

Participants

4

Reactant 2

HCID 24456Tricalcium PhosphateHCID 16760285Alendronate sodium anhydrous

Product 1

HCID 2088Alendronic Acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of calcium phosphate was prepared by introducing 100 mg of CDA into 8.75 ml of ultrapure water mixed with 1.25 ml of a 0.02 mol.l−1 sodium alendronate aqueous solution. The suspension was placed in a tube maintained at room temperature, and was stirred with a rotary stirrer at 16 rpm for 5 days. The suspension was then centrifuged and the most part of the supernatant was removed. The solid residue was filtered off, washed several times with small portions of ultrapure water, and then dried at room temperature. The resulting solid contained 7.4 wt % alendronate.

Workup

  1. customwas prepared
  2. customThe suspension was placed in a tube
  3. customthe most part of the supernatant was removed
  4. filtrationThe solid residue was filtered off
  5. washwashed several times with small portions of ultrapure water
  6. customdried at room temperature

Sources & evidence

ORD record
ord-d0464a26ba034fc48971c5617335d828
Source dataset
uspto-grants-2014_11
Patent number
US08889165B2

Linked notes

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