Piperazine → 1-(4-Ethoxy-pyridin-2-yl)-piperazine hydrochloride
Reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[CH:11]=[CH:10][N:9]=1>C(O)CCC>[ClH:7].[CH2:15]([O:14][C:12]1[CH:11]=[CH:10][N:9]=[C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[CH:13]=1)[CH3:16]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 115 °C
Procedure
860 mg piperazine was added to 350 mg 2-chloro-4-ethoxy-pyridine in 3.5 mL n-butanol. The reaction was stirred 1.5 days at 115° C. The reaction was filtered and the filtrate was washed with water and evaporated. 1N HCl was added to the residue and the precpipate was filtered to give 238 mg of the desired product. Rt: 0.3 min (method B), (M+H)+: 208
Workup
- filtrationThe reaction was filtered
- washthe filtrate was washed with water
- customevaporated
- addition1N HCl was added to the residue
- filtrationthe precpipate was filtered
Sources & evidence
- ORD record
- ord-aa29e03f2d50462e8e58c5a4ee304661
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08889677B2
Reaction notes
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