HCID 70654064, compound → HCID 178524534, compound
Reaction equation
C([O:8][C:9]1[N:17]=[C:16]([O:18]CC2C=CC=CC=2)[C:15]([F:26])=[CH:14][C:10]=1[C:11]([OH:13])=[O:12])C1C=CC=CC=1>O1CCOCC1.[OH-].[Pd+2].[OH-]>[OH:8][C:9]1[N:17]=[C:16]([OH:18])[C:15]([F:26])=[CH:14][C:10]=1[C:11]([OH:13])=[O:12]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
Next, 2,6-dibenzyloxy-5-fluoronicotinic acid (5.00 g) was dissolved in dioxane (50 mL), and 20% palladium hydroxide (50% wet, 500 mg) was added thereto and reacted under a hydrogen atmosphere for 1 hour. The palladium hydroxide was filtered through Celite from the resulting reaction product, and the solvent was evaporated to obtain a compound, i.e., 2,6-dihydroxy-5-fluoronicotinic acid (2.58 g).
Workup
- customreacted under a hydrogen atmosphere for 1 hour
- filtrationThe palladium hydroxide was filtered through Celite from the resulting reaction product
- customthe solvent was evaporated
Sources & evidence
- ORD record
- ord-109890f06e9d43a6a71242cb6e06ada2
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08889699B2
Reaction notes
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