Benzaldehyde → 1-(3-(4-Methyl-1h-imidazol-1-yl)propyl)-5-phenylimidazolidine-2,4-dione

HRID 336820

Reaction equation

HRID 336820 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][N:5]([CH2:7][CH2:8][CH2:9][NH2:10])[CH:6]=1.[CH:11](=[O:18])C1C=CC=CC=1.[CH2:19]([N+]#[C-])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[O:28]([C:30]#[N:31])[K]>>[CH3:1][C:2]1[N:3]=[CH:4][N:5]([CH2:7][CH2:8][CH2:9][N:10]2[CH:19]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[C:30](=[O:28])[NH:31][C:11]2=[O:18])[CH:6]=1

Participants

5

Reactant 4

HCID 240BenzaldehydeHCID 82558Benzyl isocyanideHCID 150349543-(4-Methyl-1H-imidazol-1-yl)propan-1-amineHCID 178418250HCID 178418250, compound

Product 1

HCID 461814181-(3-(4-Methyl-1h-imidazol-1-yl)propyl)-5-phenylimidazolidine-2,4-dione

Procedure

The compound was synthesized starting from 3-(4-methyl-1H-imidazol-1-yl)propyl amine 0.250 g (1.8 mmol), benzaldehyde 0.182 ml (1.8 mmol), benzylisonitrile 0.220 ml (1.8 mmol) pyridiniumchloride 0.210 g (1.8 mmol) and KOCN 0.150 g (1.8 mmol) as described in method 1.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-9673f797cbae4f11870c5847736e9c8b
Source dataset
uspto-grants-2014_11
Patent number
US08889709B2

Linked notes

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