Pyridoxal hydrochloride → Pyridoxal

HRID 336983

Reaction equation

HRID 336983 reaction equation
[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH:9]=[O:10])[C:5]([CH2:11][OH:12])=[CH:4][N:3]=1.Cl.C(=O)(O)[O-].[Na+]>O>[CH3:1][C:2]1[N:3]=[CH:4][C:5]([CH2:11][OH:12])=[C:6]([CH:9]=[O:10])[C:7]=1[OH:8]

Participants

4

Reactant 2

HCID 6171Pyridoxal hydrochlorideHCID 516892Sodium Bicarbonate

Product 1

HCID 1050PyridoxalYield 81.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.016 g (5 mmol) of pyridoxal hydrochloride (Aldrich) was placed in an Erlenmeyer and a solution of 0.456 g sodium bicarbonate (5.4 mmol) in 5 mL water was added. The resulting solution was set aside for some time and crystals precipitated. The thus precipitated crystals were collected by filtration, washed with cold water and dried to afford 0.68 g of the pyridoxal free base (80% yield).

Workup

  1. customprecipitated
  2. filtrationThe thus precipitated crystals were collected by filtration
  3. washwashed with cold water
  4. customdried

Sources & evidence

ORD record
ord-686c90b08eb2402bb354d6bd66fbfa1f
Source dataset
uspto-grants-2014_11
Patent number
US08889715B2

Linked notes

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