4-Isopropylaniline → (4-Isopropylphenyl)[4-(trifluoromethyl)benzyl]amine

Reaction equation

[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][CH:4]=1.[CH:13]([C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1)([CH3:15])[CH3:14]>>[CH:13]([C:16]1[CH:22]=[CH:21][C:19]([NH:20][CH2:7][C:6]2[CH:9]=[CH:10][C:3]([C:2]([F:12])([F:11])[F:1])=[CH:4][CH:5]=2)=[CH:18][CH:17]=1)([CH3:15])[CH3:14]

Participants

Reactant 2

HCID 74644-Isopropylaniline

HCID 679964-(Trifluoromethyl)benzaldehyde

Product 1

HCID 21957954(4-Isopropylphenyl)[4-(trifluoromethyl)benzyl]amine

Procedure

Following the procedure described in Example 1A, step 1, 4-(trifluoromethyl)benzaldehyde and 4-isopropylaniline gave the title compound as a pale yellow oil.

Sources & evidence

ORD record: ord-dfc5d872c6894d80806f9c35cd50f4d8
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07429666B2

Reaction notes

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