4-Isopropylaniline → N-[4-(Difluoromethoxy)benzyl]-4-isopropylaniline

HRID 33773

Reaction equation

[F:1][CH:2]([F:12])[O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[CH:6][CH:5]=1.[CH:13]([C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1)([CH3:15])[CH3:14]>>[F:1][CH:2]([F:12])[O:3][C:4]1[CH:11]=[CH:10][C:7]([CH2:8][NH:20][C:19]2[CH:21]=[CH:22][C:16]([CH:13]([CH3:15])[CH3:14])=[CH:17][CH:18]=2)=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 74644-Isopropylaniline

HCID 2736986p-(Difluoromethoxy)benzaldehyde

Product 1

HCID 29767220N-[4-(Difluoromethoxy)benzyl]-4-isopropylaniline

Procedure

Following the procedure described in Example 1A, step 1, 4-(difluoromethoxy)benzaldehyde and 4-isopropylaniline gave the title compound as a pale yellow oil.

Sources & evidence

ORD record: ord-4e58f5de8baf4e64bea011cebec2e125
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07429666B2

Linked notes

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