L-Phenylalanine → (3S)-3-amino-3-phenylpropanoic acid
Reaction equation
N[C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.O.[NH3:14]>O>[NH2:14][C@@H:3]([CH2:2][C:10]([OH:12])=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The reaction solution (250 g) containing 36 weight % (wt %) of L-phenylalanine, a bacterial cell (in an appropriate amount) of MT-11046 produced in Example 1 and water was reacted at each temperature shown in Table 6 for 24 hours or more. During the reaction, pH of the reaction solution was adjusted to 8.0 with 25% ammonia water. A solid of (S)-β-phenylalanine precipitated under all examined conditions was observed. The reaction yields of (S)-β-phenylalaninein respective temperatures are shown in Table 6.
Workup
- customwas reacted at each temperature
- waitshown in Table 6 for 24 hours or more
- customDuring the reaction, pH of the reaction solution
- customA solid of (S)-β-phenylalanine precipitated under all examined conditions
- customThe reaction yields of (S)-β-phenylalaninein respective temperatures
Sources & evidence
- ORD record
- ord-7b26176b52d04278a791b99caeb2cf0a
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08895270B2
Reaction notes
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