Stannous chloride dihydrate → 4-(6-Methoxy-1,3-benzothiazol-2-yl)aniline
Reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:11][C:12]3[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:13]=3[N:14]=2)=[CH:6][CH:5]=1)([O-])=O.O.O.[Sn](Cl)Cl>CCO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[S:11][C:12]3[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:13]=3[N:14]=2)=[CH:8][CH:9]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Prepared as described in the Nitro Reduction section using 2-(4-nitrophenyl)-6-methoxybenzothiazole (5.0 g, 17.5 mmol) and tin (II) dichloride dihydrate (31.5 g, 0.14 mol) in EtOH (150 ml) to give the title compound (4.2 g, 93%) as a colourless solid after work-up and recrystallisation from EtOH.
Workup
- customPrepared
Sources & evidence
- ORD record
- ord-15f369d2d1e442018b37cb1474605b38
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08895313B2
Reaction notes
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