Malonic Acid → 3-Amino-3-(2,5-difluorophenyl)propanoic acid
Reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[CH:4]=O.[C:11]([OH:17])(=[O:16])[CH2:12]C(O)=O.C([O-])(=O)C.[NH4+:22]>C(O)C>[NH2:22][CH:4]([C:3]1[CH:6]=[C:7]([F:10])[CH:8]=[CH:9][C:2]=1[F:1])[CH2:12][C:11]([OH:17])=[O:16]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 2,5-difluorobenzaldehyde (5 g), malonic acid (3.66 g) and ammonium acetate (5.42 g) in ethanol (50 ml) was heated under reflux for six hours. The mixture was cooled and left to stand overnight. The crystals formed were filtered off and washed with ethanol (5 ml).
Workup
- temperatureunder reflux for six hours
- temperatureThe mixture was cooled
- waitleft
- customThe crystals formed
- filtrationwere filtered off
- washwashed with ethanol (5 ml)
Sources & evidence
- ORD record
- ord-6689b046683d40b2bf586448f5338a30
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08895547B2
Reaction notes
Loading…