2-Naphthalenecarboxaldehyde → (3-Fluoropyridin-2-yl)-(naphthalen-2-yl)-methanol

HRID 34002

Reaction equation

[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][C:9]=1[CH:18]=[O:19]>>[F:1][C:2]1[C:3]([CH:18]([C:9]2[CH:10]=[CH:11][C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:8]=2)[OH:19])=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 62012-Naphthalenecarboxaldehyde

HCID 677943-Fluoropyridine

Product 1

HCID 23070214(3-Fluoropyridin-2-yl)-(naphthalen-2-yl)-methanol

Procedure

In the manner as described in Production example 1 while using 5.2 mL of 3-fluoropyridine and 10.2 g of 2-naphthaldehyde as starting materials, 3.8 g of the title compound was obtained as pale yellow needle crystals.

Sources & evidence

ORD record: ord-9e0cacbac52c4c17ac5521c24e7f1ae2
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07429609B2

Linked notes

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