Hydrochloric Acid → 5-Chloro-1H-pyrazolo(4,3-d)pyrimidine
Reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[N:10](C(=O)C)[N:9]=[CH:8][C:6]=2[N:7]=1.[OH-].[Na+].Cl>C(#N)C>[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[NH:10][N:9]=[CH:8][C:6]=2[N:7]=1Participants
5
Procedure
27 mg of 1-(5-chloro-pyrazolo[4,3-d]pyrimidin-1-yl)-ethanone was dissolved in 1.5 mL of acetonitrile, added with 1.5 mL of 5N sodium hydroxide aqueous solution, and stirred for 2 hours. After adding 2N hydrochloric acid to the reaction solution to render it acidic, the solution was extracted with ethyl acetate, and the resultant organic layer was washed with saturated brine, then dried over magnesium sulfate, and the solvent was evaporated, to afford 16 mg of the title compound.
Workup
- extractionthe solution was extracted with ethyl acetate
- washthe resultant organic layer was washed with saturated brine
- dry with materialdried over magnesium sulfate
- customthe solvent was evaporated
Sources & evidence
- ORD record
- ord-051dbe47e6fb49a4b437189075b6daeb
- Source dataset
- uspto-grants-2008_09
- Patent number
- US07429609B2
Reaction notes
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