Hydrochloric Acid → HCID 178418440, compound

HRID 3410Notes

Reaction equation

HRID 3410 reaction equation
Cl.S(OS([O-])(=O)=O)([O-])(=O)=[O:3].[NH2:11][C:12]1[N:13]=[CH:14][C:15]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19](N)=[N:18][C:16]=2[N:17]=1>O>[NH2:11][C:12]1[N:13]=[CH:14][C:15]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19]([OH:3])=[N:18][C:16]=2[N:17]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 177717DisulfateHCID 108474752,7-Diamino-6-phenylpyrido[2,3-d]pyrimidine

Product 1

HCID 178418440HCID 178418440, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 2 L of concentrated HCl and 1 L of water is added 300 g of the disulfate salt of 2,7-diamino-6-phenylpyrido[2,3-d]pyrimidine and the resulting mixture refluxed with stirring overnight. The reaction mixture is cooled in an ice bath, filtered, and the insoluble product washed with water, followed by ethanol to give 149 g of the title compound 2-amino-6-phenyl-pyrido[2,3-d]pyrimidin-7-ol, mp 390°-395° C. (darkens slowly above 350° C.).

Workup

  1. temperaturethe resulting mixture refluxed
  2. temperatureThe reaction mixture is cooled in an ice bath
  3. filtrationfiltered
  4. washthe insoluble product washed with water

Sources & evidence

ORD record
ord-8ab3a8e6f55f47d8b365c3064b07de67
Source dataset
uspto-grants-1998_03
Patent number
US05733913

Reaction notes

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