Methylhydrazine → 1-Boc-1-methylhydrazine

HRID 34112

Reaction equation

HRID 34112 reaction equation
[CH3:1][NH:2][NH2:3].[C:4]([O:8][C:9]([O:11]C(OC(C)(C)C)=O)=O)([CH3:7])([CH3:6])[CH3:5]>C(O)C>[C:4]([O:8][C:9]([N:2]([CH3:1])[NH2:3])=[O:11])([CH3:7])([CH3:6])[CH3:5]

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 90495Di-tert-butyl dicarbonate

Product 1

HCID 37482801-Boc-1-methylhydrazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

10 mL of methyl hydrazine was dissolved in 90 mL of ethanol, and under stirring at ice-cooling, a solution of 41 g of di-tert-butyldicarbonate in 90 mL of ethanol was added dropwise over 45 minutes. After stirring at room temperature for 7 hours, the solvent was evaporated, to afford 24.7 g of the title compound as a colorless oil.

Workup

  1. temperaturecooling
  2. stirringAfter stirring at room temperature for 7 hours
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-fc6875eeb4de43a8bab93f777795ac96
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Linked notes

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