Hydrochloric Acid → 1-((Dimethylamino)methyl)cyclopropanecarboxylic acid
Reaction equation
C([O:3][C:4]([C:6]1([CH2:9][N:10]([CH3:12])[CH3:11])[CH2:8][CH2:7]1)=[O:5])C.[OH-].[Na+].Cl>C(O)C>[CH3:11][N:10]([CH2:9][C:6]1([C:4]([OH:5])=[O:3])[CH2:8][CH2:7]1)[CH3:12]Participants
5
Procedure
To a solution of 222 mg of 1-dimethylaminomethyl-cyclopropane carboxylic acid ethyl ester in 0.4 mL of ethanol was added 0.1 mL of 5N sodium hydroxide aqueous solution, and stirred overnight at room temperature. The reaction solution was added with 0.5 mL of 1N hydrochloric acid, and the solvent and water were evaporated, to give 78 mg of a mixture of the title compound and sodium chloride as a white powder.
Workup
- customthe solvent and water were evaporated
Sources & evidence
- ORD record
- ord-0c5b3d9ae7dd417b88006538662a5308
- Source dataset
- uspto-grants-2008_09
- Patent number
- US07429609B2
Reaction notes
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