beta-D-Galp-(1->3)-D-GlcpN → D-Galactosamine

HRID 341729

Reaction equation

[O:1]([C@H:13]1[C@H:19]([OH:20])[C@@H:18]([CH2:21][OH:22])[O:17][CH:15]([OH:16])[C@@H:14]1[NH2:23])[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O.[O:24]([C@H:36]1[C@@H:42]([OH:43])[C@@H:41]([CH2:44][OH:45])[O:40][CH:38]([OH:39])[C@@H:37]1[NH2:46])[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O>>[OH:16][CH:15]1[O:17][C@H:18]([CH2:21][OH:22])[C@@H:19]([OH:20])[C@H:13]([OH:1])[C@H:14]1[NH2:23].[OH:39][CH:38]1[O:40][C@H:41]([CH2:44][OH:45])[C@H:42]([OH:43])[C@H:36]([OH:24])[C@H:37]1[NH2:46]

Participants

Reactant 2

HCID 91861991beta-D-Galp-(1->3)-D-GlcpN

HCID 91862027GlyTouCan:G14446DQ

Product 2

HCID 24154D-Galactosamine

HCID 439213D-Glucosamine

Procedure

Example 3-Synthesis of Galβ1-3GlcNH2 βSEt and Galβ1-3GalNH2 βSEt. See example 1, similar conditions and enzyme may be used, but instead GlcNH2 βSEt, or GalNH2 βSEt to obtain the latter product, is used as the acceptor. Here, extraction is less favorable for isolation, and instead ion-exchanger as above may be used followed by e.g. precipitation or a second chromatographic step.

Sources & evidence

ORD record: ord-5ef8e7d94c794f6c9be4623ae826bc31
Source dataset: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05856143

Linked notes

Loading…