Triethylamine → 3-(2-Ethylphenyl)-isopropyl-2-thioxo-imidazolidin-4-one

HRID 343614

Reaction equation

HRID 343614 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]=[C:10]=[S:11])[CH3:2].[CH:12]([NH:15][CH2:16][C:17](O)=[O:18])([CH3:14])[CH3:13].C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:17](=[O:18])[CH2:16][N:15]([CH:12]([CH3:14])[CH3:13])[C:10]1=[S:11])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 414244NoName_76HCID 27962132-Ethylphenyl isothiocyanate

Product 1

HCID 857015343-(2-Ethylphenyl)-isopropyl-2-thioxo-imidazolidin-4-oneYield 26%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared by the procedure described in Example 18 using 16.3 g of 2-ethylphenyl-isothiocyanate, 21.2 g of N-isopropyl glycine, 21.0 g of triethyl amine, and 300 mL of chloroform. Crystallization from diethyl ether afforded the title compound (6.8 g) as a white solid, m.p. 103°-105° C. Anal. Calcd. for. C14H18N2OS: C, 64.09; H, 6.92; N, 10.68. Found: C, 64.08; H, 6.92; N, 10.62. Mass spectrum (EI, M.+) m/z 262.

Workup

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from diethyl ether

Sources & evidence

ORD record
ord-8ba271c0a41747f5a8261f2957fe13f9
Source dataset
uspto-grants-1999_01
Patent number
US05861517

Linked notes

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