Triethylamine → 1-Isopropyl-3-(2-isopropylphenyl)2-thioxo-imidazolidin-4-one

HRID 343615

Reaction equation

HRID 343615 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]=[C:11]=[S:12])([CH3:3])[CH3:2].[CH:13]([NH:16][CH2:17][C:18](O)=[O:19])([CH3:15])[CH3:14].C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH:13]([N:16]1[CH2:17][C:18](=[O:19])[N:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:1]([CH3:3])[CH3:2])[C:11]1=[S:12])([CH3:15])[CH3:14]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1420522-Isopropylphenyl isothiocyanateHCID 414244NoName_76

Product 1

HCID 867497971-Isopropyl-3-(2-isopropylphenyl)2-thioxo-imidazolidin-4-oneYield 43.6%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared by the procedure described in Example 18 using 10.0 g of 2-isopropylphenyl-isothiocyanate, 11.9 g of N-isopropyl glycine, 12.0 g of triethyl amine, and 200 mL of chloroform. Crystallization from ethanol afforded the title compound (6.8 g) as a light pink solid, m.p. 112°-114° C. Anal. Calcd. for. C15H20N2OS: C, 65.18; H, 7.29; N, 10.13. Found: C, 65.51; H, 7.25; N, 10.32. Mass spectrum (EI, M.+) m/z 276.

Workup

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from ethanol

Sources & evidence

ORD record
ord-42804dbe06c14569a567ce221e26f5a2
Source dataset
uspto-grants-1999_01
Patent number
US05861517

Linked notes

Loading…