Reaction equation
O.[NH2:2][NH2:3].[NH2:4][NH:5][C:6]([NH:8][NH2:9])=[S:7].[CH2:10](O)C>>[NH:2]([C:10]1[N:8]([NH2:9])[C:6]([SH:7])=[N:5][N:4]=1)[NH2:3]Participants
4
Procedure
Methyl dithiocarbazinate (24.4 gm., 0.2 mole) was dissolved in 200 ml. of absolute ethanol and 18 ml. (0.3 mole of hydrazine) of 85% hydrazine hydrate was added. The resulting solution was refluxed until no more solid thiocarbohydrazide precipitated (about 45 minutes). A small amount of 3-hydrazino-4-amino-5-mercapto-1,2,4-triazole that had formed was removed as follows. The reaction mixture was chilled, and the resulting solid product was collected and recrystallized from water acidified with a few drops of hydrochloric acid.
Workup
- dissolutionMethyl dithiocarbazinate (24.4 gm., 0.2 mole) was dissolved in 200 ml
- customprecipitated (about 45 minutes)
Sources & evidence
- ORD record
- ord-08e9a74d1a7542d2a0d7933094d2c14d
- Source dataset
- uspto-grants-1999_01
- Patent number
- US05861526
Linked notes
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