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Ammonia → 2-Amino-5-chloro-3-nitrobenzotrifluoride

HRID 343838
Notes
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Reaction equation

HRID 343838 reaction equation
[N+:1]([C:4]1[C:5](Cl)=[C:6]([C:11]([F:14])([F:13])[F:12])[CH:7]=[C:8]([Cl:10])[CH:9]=1)([O-:3])=[O:2].[NH3:16]>[Cl-].C([N+](CC)(CC)CC)C.O>[NH2:16][C:5]1[C:4]([N+:1]([O-:3])=[O:2])=[CH:9][C:8]([Cl:10])=[CH:7][C:6]=1[C:11]([F:14])([F:13])[F:12]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 222AmmoniaHCID 136718542,5-Dichloro-1-nitro-3-(trifluoromethyl)benzene

Product 1

HCID 27376442-Amino-5-chloro-3-nitrobenzotrifluoride

Reagents, catalysts & solvents 2

HCID 5946Tetraethylammonium ChlorideCatalystHCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

260 g of 3-nitro-2,5-dichlorobenzotrifluoride, 130 ml of water and 10 g of tetraethylammonium chloride were introduced into an autoclave, and 120 ml of liquid ammonia were injected. The mixture was then heated to 130° C. and stirred for 10 hours at this temperature. After cooling, the batch was filtered and the precipitate which had been separated off was washed with water and dried. 194 g of 2-amino-3-nitro-5-chloro-benzotrifluoride with a melting point of 67° C. were obtained.

Workup

  1. temperatureAfter cooling
  2. filtrationthe batch was filtered
  3. customthe precipitate which had been separated off
  4. washwas washed with water
  5. customdried

Sources & evidence

ORD record
ord-e45f04a2d69a4d4fba4ee5d64ca4fe84
Source dataset
uspto-grants-1999_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05863933

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes