Hydrochloric Acid → 3-Amino-2-chloro-5-fluoro-4-methylbenzoic acid
Reaction equation
[Cl:1][C:2]1[C:10]([N+:11]([O-])=O)=[C:9]([CH3:14])[C:8]([F:15])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[O-]S(S([O-])=O)=O.[Na+].[Na+].Cl>COCCO.O>[NH2:11][C:10]1[C:2]([Cl:1])=[C:3]([CH:7]=[C:8]([F:15])[C:9]=1[CH3:14])[C:4]([OH:6])=[O:5]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
18.5 g of 2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid and 51.5 g of Na2S2O4 are boiled in a mixture of 160 ml of glycol monomethyl ether and 160 g of water for 3 hours. 230 ml of 1/2-concentrated HCl are added to the still warm solution. The mixture is boiled up once more, cooled and poured into 560 ml of water. The solid which has precipitated is isolated and dried. Yield: 12.4 g, melting point: 182°-84°.
Workup
- temperaturecooled
- customThe solid which has precipitated
- customis isolated
- customdried
Sources & evidence
- ORD record
- ord-59d9ecf81f1c4d51bdbef875b42cf00b
- Source dataset
- uspto-grants-1988_08
- Patent number
- US04762844
Reaction notes
Loading…