Acetic Acid → 6-Methoxy-2-naphthylacetic acid

HRID 346445

Reaction equation

HRID 346445 reaction equation
C(Cl)(Cl)Cl.[CH3:5]O.O.[CH3:8][O:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=1.[CH2:18](O)[CH3:19].S(=O)(=O)(O)O.[C:26]([OH:29])(=[O:28])[CH3:27]>>[CH3:8][O:9][C:10]1[CH:17]=[C:16]2[C:13](=[CH:12][CH:11]=1)[CH:14]=[C:19]([CH2:27][C:26]([OH:29])=[O:28])[CH:18]=[CH:5]2

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 702EthanolHCID 1118Sulfuric AcidHCID 312444-MethoxybenzaldehydeHCID 21866399Chloroform methanol water

Product 1

HCID 321766-Methoxy-2-naphthylacetic acid

Procedure

The final products, i.e. the phospholipid-drug conjugates obtained at the end of step 6, were subjected to TLC analysis under the following conditions: Silica gel 60 on aluminum sheet. Eluent is chloroform:methanol:water (65:35:5 v/v). Indicator is a spray of the composition: 4-methoxybenzaldehyde (10 ml), absolute ethanol (200 ml), 98% sulfuric acid (10 ml) and glacial acetic acid (2 ml). The chromatogram is sprayed with the indicator and then charred at 100° C.

Workup

  1. customcharred at 100° C.

Sources & evidence

ORD record
ord-ebb8d678259740259b882bd91435c301
Source dataset
uspto-grants-2007_02
Patent number
US07173018B2

Linked notes

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