Diisopropylethylamine → 1-[7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-2-methoxy-ethanone

HRID 346448

Reaction equation

HRID 346448 reaction equation
Cl.[F:2][C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[CH2:6][O:7][C:8]1[CH:18]=[CH:17][C:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16][C:10]=2[CH:9]=1.[CH3:22][O:23][CH2:24][C:25](Cl)=[O:26].C(N(C(C)C)C(C)C)C>>[F:2][C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[CH2:6][O:7][C:8]1[CH:18]=[CH:17][C:11]2[CH2:12][CH2:13][N:14]([C:25](=[O:26])[CH2:24][O:23][CH3:22])[CH2:15][CH2:16][C:10]=2[CH:9]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 96623Methoxyacetyl chlorideHCID 210801847-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride

Product 1

HCID 117722731-[7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-2-methoxy-ethanoneYield 98%

Procedure

The title compound was prepared in analogy to Example 1 d) from 7-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride [Example 1c)] and methoxy-acetic acid chloride with N-ethyl-diisopropylamine as the base. Yield: 98% of theory as a colourless oil; MS: m/e=344 (M+H)+.

Workup

  1. customwas prepared in analogy to Example 1 d

Sources & evidence

ORD record
ord-b968ccedd0584457b42b4a3c19d603ac
Source dataset
uspto-grants-2007_02
Patent number
US07173023B2

Linked notes

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