7-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride → HCID 11221548, compound

HRID 346449

Reaction equation

HRID 346449 reaction equation
C([O:3][C:4](=O)[C:5]([N:7]1[CH2:13][CH2:12][C:11]2[CH:14]=[C:15]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)[CH:16]=[CH:17][C:10]=2[CH2:9][CH2:8]1)=[O:6])C.Cl.FC1C=C(C=CC=1)COC1C=CC2CC[NH:41]CCC=2C=1.C([ClH]C(=O)C(Cl)=O)C>C(N(CC)CC)C>[F:26][C:22]1[CH:21]=[C:20]([CH:25]=[CH:24][CH:23]=1)[CH2:19][O:18][C:15]1[CH:16]=[CH:17][C:10]2[CH2:9][CH2:8][N:7]([C:5](=[O:6])[C:4]([NH2:41])=[O:3])[CH2:13][CH2:12][C:11]=2[CH:14]=1

Participants

4

Reactant 2

HCID 210801847-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochlorideHCID 69291666HCID 69291666, compound

Product 1

HCID 11221548HCID 11221548, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

[7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-oxo-acetic acid ethyl ester: The title compound was prepared in analogy to Example 1d) from 7-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride [Example 1c)] and ethyl oxalic acid chloride with triethylamine as the base. Yield: 88% of theory as a colourless oil; MS: m/e=372 (M+H)+.

Sources & evidence

ORD record
ord-9c9c2595a27844f3a998bcc46fd854a8
Source dataset
uspto-grants-2007_02
Patent number
US07173023B2

Linked notes

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