Potassium Hydroxide → N-(hydroxyethoxyethoxyethyl)pyrrolidine
Reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH2:7][CH2:8][O:9][CH2:10][CH2:11][O:12][CH:13](O)[CH3:14].[OH-:16].[K+]>C(O)C>[OH:16][CH2:7][CH2:8][O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A total of 295 g of pyrrolidine and 250 g of 2-chloroethoxyethoxyethanol in 750 ml of ethanol was refluxed for 5 hours. The reaction mixture was then treated with 106 g of KOH and refluxed for an additional hour. Filtration and distillation yielded 229 g of N-(hydroxyethoxyethoxyethyl)pyrrolidine (b.p.=145° C. at 3 mm).
Workup
- temperaturerefluxed for an additional hour
- filtrationFiltration and distillation
Sources & evidence
- ORD record
- ord-1ee06e1127574b56afdc6df850dc1086
- Source dataset
- uspto-grants-1988_08
- Patent number
- US04762934
Reaction notes
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