1,1,1-Trifluoro-2-isothiocyanatoethane → HCID 178485065, compound

HRID 34757

Reaction equation

HRID 34757 reaction equation
[F:1][C:2]([F:8])([F:7])[CH2:3][N:4]=[C:5]=[S:6].[NH2:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][S:16][CH2:17][CH2:18][NH:19][C:20]([NH:24][CH3:25])=[N:21][C:22]#[N:23])[N:14]=1>CN(C)C=O>[F:1][C:2]([F:8])([F:7])[CH2:3][NH:4][C:5](=[S:6])[NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][S:16][CH2:17][CH2:18][NH:19][C:20]([NH:24][CH3:25])=[N:21][C:22]#[N:23])[N:14]=1

Participants

4

Reactant 2

HCID 138837771,1,1-Trifluoro-2-isothiocyanatoethaneHCID 178485066HCID 178485066, compound

Product 1

HCID 178485065HCID 178485065, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2,2,2-trifluoroethyl isothiocyanate (0.68 g.) and 2-amino-4-[2-(2-cyano-3-methylguanidino)ethylthiomethyl]thiazole (1.08 g.) in dimethylformamide (5 ml.) was maintained at 60° for 4 hours and then evaporated to dryness. The residue was recrystallised from acetonitrile to give 2-[3-(2,2,2-trifluoroethyl)thioureido]-4-[2-(2-cyano-3-methylguanidino)ethylthiomethyl]thiazole, m.p. 157°-158°.

Workup

  1. temperaturewas maintained at 60° for 4 hours
  2. customevaporated to dryness
  3. customThe residue was recrystallised from acetonitrile

Sources & evidence

ORD record
ord-5372c98e3cfb479abc30ca7e91934a83
Source dataset
uspto-grants-1988_08
Patent number
US04762932

Linked notes

Loading…