Iodoethane → 2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-1-ethyl-

Reaction equation

[O:1]=[C:2]1[NH:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[NH:5][CH2:4][CH2:3]1.[CH2:13](I)[CH3:14]>>[CH2:13]([N:8]1[C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[NH:5][CH2:4][CH2:3][C:2]1=[O:1])[CH3:14]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 2237712,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

Product 1

HCID 30782002H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-1-ethyl-

Procedure

2-Oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine (1.95 g, 11.96 mmol) was reacted with ethyl iodide (1.4 ml, 17.5 mmol) according to the procedure in Example 18A. The product was purified by flash chromatography on silica (eluant EtOAc); yield 1.70 g (75%).

Workup

customThe product was purified by flash chromatography on silica (eluant EtOAc)

Sources & evidence

ORD record: ord-c59cc29e10ad497786d80d9cece45616
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07176195B2

Reaction notes

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