Pyridine-2-acetonitrile → 6-Pyridin-2-yl-pyrido[2,3-d]pyrimidine-2,7-diamine

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]#[N:9].[NH2:10][C:11]1[N:16]=[C:15]([NH2:17])[C:14]([CH:18]=O)=[CH:13][N:12]=1>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:8]([NH2:9])=[N:17][C:15]2[N:16]=[C:11]([NH2:10])[N:12]=[CH:13][C:14]=2[CH:18]=1

Participants

Reactant 2

HCID 75959Pyridine-2-acetonitrile

HCID 3091762,4-Diaminopyrimidine-5-carbaldehyde

Product 1

HCID 218500586-Pyridin-2-yl-pyrido[2,3-d]pyrimidine-2,7-diamine

Procedure

The procedure of Example 1 was followed to react 0.84 mL of 2-pyridylacetonitrile and 1.0 g of 2,4-diamino-5-pyrimidinecarboxaldehyde to afford the title compound, mp 312°-321° C.

Sources & evidence

ORD record: ord-1d437903b7d7465cbd657fadc7a517dd
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05733913

Reaction notes

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