Hydrochloric Acid → 2-Amino-4-(benzyloxy)butan-1-ol Hydrochloride
Reaction equation
[CH2:1]([O:8][CH2:9][CH2:10][CH:11]([NH:14]C(=O)OC(C)(C)C)[CH2:12][OH:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:22]>O1CCOCC1>[ClH:22].[NH2:14][CH:11]([CH2:10][CH2:9][O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:12][OH:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
tert-Butyl 3-(benzyloxy)-1-(hydroxymethyl)propylcarbamate (5 g, 17 mmol) is dissolved in 4 N hydrochloric acid in dioxane (21 mL) and stirred for 3 h at room temperature. The solution is concentrated under reduced pressure to give the title compound in pure form. ESI MS m/z 196.1 [M+H]+.
Workup
- concentrationThe solution is concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-2b78f1cc2bc24b6a82c3a517d95c8c4e
- Source dataset
- uspto-grants-2007_02
- Patent number
- US07176242B2
Reaction notes
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