Carbon Dioxide → Neopeltolide

HRID 349602

Reaction equation

HRID 349602 reaction equation
CCN([CH2:6][CH2:7][O:8][C:9]([C:11]1[CH:16]=[CH:15][C:14](N)=[CH:13][CH:12]=1)=[O:10])CC.CC1(C)S[C@@H]2[C@H](NC([CH2:30][C:31]3[CH:36]=C[CH:34]=[CH:33][CH:32]=3)=O)C(=O)N2[C@H]1C(O)=O.[OH2:41].[NH2:42][C@H:43](C(O)=O)[CH2:44][CH2:45][C:46](=[O:48])[NH2:47].C1N(C[CH2:59][OH:60])CCN(CCS(O)(=O)=O)C1.CC(NC)C1O[CH:73]([O:75][CH:76]2[CH:81](O)[CH:80]([O:83][CH:84]3[O:89]CC(O)(C)[CH:86](NC)[CH:85]3O)[CH:79](N)[CH2:78][CH:77]2N)C(N)CC1.[C:100](=O)=[O:101]>>[CH3:77][CH2:78][CH2:79][C@H:80]1[O:83][C:84](=[O:89])[CH2:85][C@@H:86]2[O:41][C@@H:33]([CH2:34][C@@H:7]([O:8][C:9](/[CH:11]=[CH:16]\[CH2:15][CH2:14][C:13]3[N:47]=[C:46](/[CH:45]=[CH:44]\[CH2:43][NH:42][C:100]([O:60][CH3:59])=[O:101])[O:48][CH:12]=3)=[O:10])[CH2:6]2)[CH2:32][C@@H:31]([CH3:30])[CH2:36][C@@H:76]([O:75][CH3:73])[CH2:81]1

Participants

6

Reactant 5

HCID 280Carbon DioxideHCID 3467GentamicinHCID 5961L-GlutamineHCID 225024-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)-(2S,5R,6R)-, compd. with 2-(diethylamino)ethyl 4-aminobenzoate, hydrate (1:1:1)HCID 238314-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid

Product 1

HCID 16115403Neopeltolide

Procedure

All cell lines are maintained in Roswell Park Memorial Institute (RPMI) medium 1640 supplemented with 100 U/mL penicillin 100 μg/ml streptomycin, 60 μg/ml L-glutamine, 18 mM HEPES, 0.05 mg/mL gentamycin and 10% fetal bovine serum. Cell lines are cultured in plastic tissue culture flasks and kept in an incubator at 37° C. in humidified air containing 5% CO2.

Workup

  1. temperatureAll cell lines are maintained in Roswell Park Memorial Institute (RPMI) medium 1640
  2. customCell lines are cultured in plastic tissue culture flasks
  3. customkept in an incubator at 37° C. in humidified air

Sources & evidence

ORD record
ord-54430c6430da44529262d57f7ce4b87f
Source dataset
uspto-grants-2007_02
Patent number
US07179828B2

Linked notes

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