Oxalyl chloride → 2-Chloro-4,5-difluorobenzoyl Isocyanate

HRID 349728Notes

Reaction equation

HRID 349728 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:14](Cl)=[O:15]>ClCCl>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([N:6]=[C:14]=[O:15])=[O:5]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 23171512-Chloro-4,5-difluorobenzamide

Product 1

HCID 115575832-Chloro-4,5-difluorobenzoyl Isocyanate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Chloro-4,5-difluorobenzamide was dissolved in dichloromethane, admixed with 1.5 eq. of oxalyl chloride and heated to reflux for 16 hours. The reaction mixture was concentrated under high vacuum and reacted in stage b without further purification.

Workup

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. concentrationThe reaction mixture was concentrated under high vacuum
  4. customreacted in stage b without further purification

Sources & evidence

ORD record
ord-37b2489659b54d3c86a3d1c2a4eced91
Source dataset
uspto-grants-2007_02
Patent number
US07179941B2

Reaction notes

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