Oxalic acid dihydrate → N-[1-(4-methoxyphenyl)-3-piperidinopropyl]quinaldinamide oxalate

HRID 35010

Reaction equation

HRID 35010 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:18][C:19]([CH2:21][C:22]2[CH:31]=[CH:30][C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[N:23]=2)=[O:20])[CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:5][CH:4]=1.O.O.[C:34]([OH:39])(=[O:38])[C:35]([OH:37])=[O:36]>>[C:34]([OH:39])(=[O:38])[C:35]([OH:37])=[O:36].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]([NH:18][C:19]([CH2:21][C:22]2[CH:31]=[CH:30][C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[N:23]=2)=[O:20])[CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 61373Oxalic acid dihydrateHCID 67930051N-[1-(4-methoxyphenyl)-3-piperidinopropyl]quinaldinamide

Product 1

HCID 67930076N-[1-(4-methoxyphenyl)-3-piperidinopropyl]quinaldinamide oxalateYield 70%

Procedure

The procedure of Example 7 was repeated using 1.03 g (2.56 mmol.) of N-[1-(4-methoxyphenyl)-3-piperidinopropyl]quinaldinamide and 323 mg (2.56 mmol.) of oxalic acid dihydrate, to obtain 884 mg (yield: 70%) of the subject compound as a white powdery product upon recrystallization from 8 ml of ethanol.

Sources & evidence

ORD record
ord-5116b757d2fc4b29bf10d174261fb24e
Source dataset
uspto-grants-1988_08
Patent number
US04764617

Linked notes

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