Hydrochloric Acid → 3-Hydroxy-4-methoxypicolinic acid hydrochloride

HRID 350652

Reaction equation

HRID 350652 reaction equation
C([O:8][C:9]1[C:10]([C:17]([OH:19])=[O:18])=[N:11][CH:12]=[CH:13][C:14]=1[O:15][CH3:16])C1C=CC=CC=1.[ClH:20]>CO>[ClH:20].[OH:8][C:9]1[C:10]([C:17]([OH:19])=[O:18])=[N:11][CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 199602893-Benzyloxy-4-methoxypicolinic acid

Product 1

HCID 694976023-Hydroxy-4-methoxypicolinic acid hydrochlorideYield 54.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-Benzyloxy-4-methoxypicolinic acid (8.3 g) was dissolved in 100 ml of methanol. Concentrated hydrochloric acid (2 ml) was added to the solution. The mixture was heated under reflux for 30 min. The reaction solution was concentrated under the reduced pressure. The residue was recrystallized from water-ethanol to give 3.6 g (yield 54.8%) of title compound as colorless powder.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 30 min
  3. concentrationThe reaction solution was concentrated under the reduced pressure
  4. customThe residue was recrystallized from water-ethanol

Sources & evidence

ORD record
ord-a78ece4b9afc480db0193fba1d565803
Source dataset
uspto-grants-2007_02
Patent number
US07183278B1

Linked notes

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