Ethyl methanesulfonylacetate → Ethyl 3-dimethylamino-2-methylsulphonylacrylate

HRID 351653

Reaction equation

HRID 351653 reaction equation
[CH3:1][S:2]([CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:4])=[O:3].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>>[CH3:13][N:14]([CH3:16])[CH:15]=[C:5]([S:2]([CH3:1])(=[O:4])=[O:3])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

3

Reactant 2

HCID 78201Ethyl methanesulfonylacetateHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 57126670Ethyl 3-dimethylamino-2-methylsulphonylacrylate

Conditions

Temperature
85 °C

Procedure

6.65 g (40 mmol) of ethyl methanesulphonylacetate and 5.72 g (48 mmol) of N,N-dimethylformamide dimethyl acetal are admixed and heated at 85° C. overnight. The solution is concentrated using a rotary evaporator, and the solid is comminuted with cyclohexane and filtered off with suction.

Workup

  1. concentrationThe solution is concentrated
  2. customa rotary evaporator
  3. customthe solid is comminuted with cyclohexane
  4. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-d5b98d3c965f4e9796d425aac5851886
Source dataset
uspto-grants-2004_06
Patent number
US06743798B1

Linked notes

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