Sodium Hydroxide → 3,4-Dihydro-2H-1,4-benzoxazine
Reaction equation
O=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[O:4][CH2:3]1.B#B.[OH-].[Na+]>O1CCCC1>[O:4]1[C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[NH:7][CH2:2][CH2:3]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
3,4-Dihydro-3-oxo-1,4(2H)-benzoxazine was refluxed for several hours in one equivalent of diborane in tetrahydrofuran. Excess sodium hydroxide solution was added, the product was extracted with ether and the solvent was evaporated to give the title compound as an oil.
Workup
- extractionthe product was extracted with ether
- customthe solvent was evaporated
Sources & evidence
- ORD record
- ord-4e559cf6b812488bb588a627a636cd16
- Source dataset
- uspto-grants-1988_08
- Patent number
- US04766118
Reaction notes
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