Sodium Carbonate → HCID 15612244, compound

HRID 35194

Reaction equation

HRID 35194 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:18]4([CH3:23])OCC[O:19]4)[CH:14]=3)[CH:9]=2)[CH:2]=1.C(=O)([O-])[O-].[Na+].[Na+]>Cl>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:18](=[O:19])[CH3:23])[CH:14]=3)[CH:9]=2)[CH:2]=1

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 156122432-(3-Pyridylmethyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene

Product 1

HCID 15612244HCID 15612244, compoundYield 101.3%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 150 mg of 2-(3-pyridylmethyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene in 15 ml of 1N hydrochloric acid was allowed to stand for 3 hours at room temperature. The solution was neutralized with sodium carbonate and extracted with methylene chloride. The organic layer was dried over sodium sulfate and the solvent removed under reduced pressure to give 130 mg of 2-(3-pyridylmethyl)-6-acetylnaphthalene as an oil.

Workup

  1. extractionextracted with methylene chloride
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-d087129627ad4ec4a8be14aecff590ba
Source dataset
uspto-grants-1988_08
Patent number
US04766127

Linked notes

Loading…