4-Nitrophenol → 2-Bromo-4-nitrophenol

Reaction equation

[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[Br:11]N1C(=O)CCC1=O>>[Br:11][C:8]1[CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[CH:6][C:7]=1[OH:10]

Participants

Reactant 2

HCID 9804-Nitrophenol

HCID 67184N-bromobutanimide

Product 1

HCID 221092-Bromo-4-nitrophenol

Procedure

2-Bromo-4-nitrophenol was prepared by reaction of 4-nitrophenol and N-bromosuccinimide. The experimental method of preparation was described by T. Oberhouser in J. Org. Chem. 1997 (62), page 4504.

Workup

customThe experimental method of preparation

Sources & evidence

ORD record: ord-042bb957e7284d5095298c8c211de81c
Source dataset: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06749644B2

Reaction notes

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