HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosulfonic acid → 6-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosulfonic acid | HCID 24638 | — |
| Reactant | 2-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide | HCID 21296915 | — |
| Product | 6-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane | HCID 21296931 | — |
Reaction Steps
70 g (0.29 mole) of 6-(N-chloroacetylaminomethyl)-5-hydroxyindane are dissolved in 150 ml of chlorosulfonic acid, and the mixture is stirred for approx. 30 minutes at room temperature. The mixture is poured into ice water and the product is filtered off with suction. The initially crystalline material becomes oily after a little time and is employed in the next stage in this form without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04766241 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-602c8eb7a33141f29baf3356b4e49d0a |
| Source note | uspto-grants-1988_08 |