(1,4-Diazepan-1-yl)(furan-2-yl)methanone → 1-(Tetrahydrofuran-2-ylcarbonyl)-1,4-diazepane
Reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([N:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7]>[Rh].C(O)C>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]([N:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
N-(2-Furoyl)homopiperazine (33.0 g.) in 200 ml. of ethanol was hydrogenated over 5% rhodium-on-carbon catalyst at three atmospheres pressure. The catalyst was removed by filtration and the product distilled to give the desired product, B.P. 135° at 1 mm.
Workup
- customThe catalyst was removed by filtration
- distillationthe product distilled
Sources & evidence
- ORD record
- ord-52064a5f0b7744a1bfc854a0c8935f0d
- Source dataset
- uspto-grants-1983_03
- Patent number
- US04377581
Reaction notes
Loading…