Formamide → 4-Aminoquinazoline

HRID 354843

Reaction equation

HRID 354843 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH:10]([NH2:12])=O>>[NH2:5][C:4]1[C:3]2[C:2](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:1]=[CH:10][N:12]=1

Participants

3

Reactant 2

HCID 713FormamideHCID 729132-Aminobenzonitrile

Product 1

HCID 847594-Aminoquinazoline

Conditions

Temperature
220 °C

Procedure

A mixture of o-aminobenzonitrile (22.58 g) and formamide (96 ml) was refluxed for 2 hours at 220° C. After the resultant mixture was cooled to ambient temperature, precipitated crystals were separated by filtration, washed twice with a small volume of water and dried under reduced pressure to give crystalline 4-aminoquinazoline (17.0 g).

Workup

  1. customprecipitated crystals
  2. customwere separated by filtration
  3. washwashed twice with a small volume of water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-5deb0920a34d494fb43b1e7b80c6165f
Source dataset
uspto-grants-1983_03
Patent number
US04377580

Linked notes

Loading…