5-(trifluoromethyl)-1H-indole → 5-(trifluoromethyl)-2,3-dihydro-1H-indole
Reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[CH:6]2.C([BH3-])#N.[Na+]>C(O)(=O)C>[F:13][C:2]([F:1])([F:12])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH2:7][CH2:6]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
5-Trifluoromethylindole (D42) was reduced in the usual way with sodium cyanoborohydride in glacial acetic acid to give the title compound (D43) (0.18 g, 83%)
Sources & evidence
- ORD record
- ord-deee3ed489584b6381f46b6427a12cf6
- Source dataset
- uspto-grants-1998_11
- Patent number
- US05834494
Reaction notes
Loading…