Ethyl Acetate → HCID 10632473, compound

HRID 356042Notes

Reaction equation

HRID 356042 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([CH3:13])=[CH:6][C:3]=1[CH:4]=[O:5].B(O[O-])=[O:15].[Na+].C(OCC)(=O)C>C(O)(=O)C>[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([CH3:13])=[CH:6][C:3]=1[C:4]([OH:15])=[O:5]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 517072Sodium Perborate2×HCID 10821873HCID 10821873, compound

Product 1

HCID 10632473HCID 10632473, compoundYield 77.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2-chloro-5-methyl-4-nitrobenzaldehyde (1.72 g, 8.6 mmol) in acetic acid (20 ml) at 80° C. was treated with sodium perborate (2.64 g, 17.2 mmol). After 0.5 h a further portion of sodium perborate (1.32 g, 8.6 mmol) was added. After 0.25 h the reaction mixture was added to ethyl acetate--half saturated brine, and the organic extract dried (Na2SO4) and evaporated, affording the title product as a white solid (1.43 g, 77%).

Workup

  1. extractionhalf saturated brine, and the organic extract
  2. dry with materialdried (Na2SO4)
  3. customevaporated

Sources & evidence

ORD record
ord-9c2c01ed0f344a57b267f2a70854d008
Source dataset
uspto-grants-1998_11
Patent number
US05834494

Reaction notes

Loading…