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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 356151Generated: October 25, 2026

Ethanol hydrochloride → (3aR*,10aS*)-9-Benzyl-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one hydrochloride

https://huagongshe.com/reaction/356151

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthanol hydrochlorideHCID 21887872—
Reactant(3aR*,10aS*)-9-benzyl-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta [e][1,4]diazepin-10(1H)-oneHCID 70109795—
SolventEthanolHCID 702—
Product(3aR*,10aS*)-9-Benzyl-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one hydrochlorideHCID 70111935—

Reaction Steps

In ethanol was dissolved (3aR*,10aS*)-9-benzyl-2,3,3a,4,9,10a-hexahydrobenzo[b]cyclopenta[e][1,4]diazepin-10(1H)-one. To the solution was added dropwise a 2.5N HCl-ethanol solution, and the mixture was concentrated under reduced pressure. The concentrate was recrystallized from ethanol-ether to give the titled compound. m.p. 145°-148° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05834463
Source datasetuspto-grants-1998_11
ORD IDord-73df44f84f6d41899bb8ef19f4c809a0
Source noteuspto-grants-1998_11