Imidazole → HCID 18798666, compound

HRID 356466

Reaction equation

HRID 356466 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10](=[O:12])[CH3:11])=[CH:4][CH:3]=1.[C:13]([Si:17](Cl)([CH3:19])[CH3:18])([CH3:16])([CH3:15])[CH3:14].N1C=CN=C1>CN(C=O)C>[Si:17]([O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10](=[O:12])[CH3:11])=[CH:6][CH:7]=1)([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:19])[CH3:18]

Participants

5

Reactant 3

HCID 795ImidazoleHCID 216484-(4'-Hydroxyphenyl)-2-butanoneHCID 28928tert-Butyldimethylsilyl chloride

Product 1

HCID 18798666HCID 18798666, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared as described in General Method 5 using 10 g (60.9 mmol) of 4-(4-hydroxyphenyl)-2-butanone, 10.1 g (67 mmol) of tert-butyldimethyl silyl chloride, 4.56 g (67 mmol) of imidazole and 150 mL of DMF. The crude product was carried on "as is" to the next step (see Example KK).

Sources & evidence

ORD record
ord-ffc34ceb05ed44a58e42ad7c9732bf74
Source dataset
uspto-grants-1998_11
Patent number
US05834506

Linked notes

Loading…