Hydrochloric Acid → Methyl 12-aminododecanoate

HRID 356883

Reaction equation

HRID 356883 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14].Cl.[CH3:17]O>>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH3:17])=[O:14]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6966112-Aminododecanoic Acid

Product 1

HCID 3665980Methyl 12-aminododecanoateYield 98%

Procedure

To a suspension of 12-aminododecanoic acid (5.00 g, 23.3 mmol) in anhydrous MeOH (90 mL) was introduced hydrogen chloride gas for 25 minutes, during which time the suspension became clear. The solution was then stirred at room temperature for 3 hours and the solvent was removed in vacuo. The white solid residue was dissolved in H2O. Solid NaHCO3 was added to neutralize the solution to pH 8-9. The white precipitates thus formed were collected by vacuum filtration (5.20 g) (Yield: 98%).

Workup

  1. customthe solvent was removed in vacuo
  2. dissolutionThe white solid residue was dissolved in H2O
  3. additionSolid NaHCO3 was added
  4. customThe white precipitates thus
  5. customformed
  6. filtrationwere collected by vacuum filtration (5.20 g) (Yield: 98%)

Sources & evidence

ORD record
ord-556f974df338495bab3fc6a50f4c8596
Source dataset
uspto-grants-1998_11
Patent number
US05840733

Linked notes

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