Hydrochloric Acid → HCID 178429829, compound

HRID 357019

Reaction equation

HRID 357019 reaction equation
Br.Cl[C:3]1[N:8]2[CH:9]=[C:10]([CH3:12])[N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1.Cl.[SH-:14].[Na+]>>[SH:14][C:3]1[N:8]2[CH:9]=[C:10]([CH3:12])[N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 28015Sodium hydrosulfideHCID 189367145-Chloro-2-methylimidazo[1,2-a]pyridine hydrobromide

Product 1

HCID 178429829HCID 178429829, compound

Conditions

Temperature
90 °C

Procedure

In a nitrogen atmosphere, 17.33 g (70 mmol) of 5-chloro-2-methylimidazo[1,2-a]pyridine hydrobromide was added to 70 ml of a sodium hydrosulfide solution at room temperature, followed by stirring at 90° C. for 24 hours. After the reaction mixture was cooled, concentrated hydrochloric acid was added until the reaction mixture's pH became 3-4. The resulting precipitate was collected by filtration, washed with water and dried to yield 12.32 g (quant, yellow powder) of the desired product.

Workup

  1. temperatureAfter the reaction mixture was cooled
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-360c8d344a814fb89121864914482dc8
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Linked notes

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