Methanol → 1-Methyl-3,5-diphenylpyrazole

HRID 357533

Reaction equation

[C:1]1([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18]S(O)(=O)=O.CO>>[CH3:18][N:8]1[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:11][C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:9]1

Participants

Reactant 3

HCID 887Methanol

HCID 6395Methanesulfonic Acid

HCID 708401H-Pyrazole, 3,5-diphenyl-

Product 1

HCID 1405171-Methyl-3,5-diphenylpyrazoleYield 948.5%

Procedure

As in Example 2, a melt of 10 g (0.0455 mol) of 3,5-diphenylpyrazole and 0.44 g (0.0045 mol) of methanesulfonic acid was introduced and reacted over the course of 4 hours with 175 g (5.46 mol) of gaseous methanol (vaporized at 160° C.). 10 g (92%) of 1-methyl-3,5-diphenylpyrazole were obtained, boiling point 190° C./3 mbar, with a content of 98% (GC).

Sources & evidence

ORD record: ord-ecba16ab115c4fee89da7469d20c363f
Source dataset: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05840913

Linked notes

Loading…