Hydrazine hydrate (1:1) → (Z)-7-Aminohept-5-enoic Acid
Reaction equation
O.NN.C1(=O)[N:8]([CH2:9]/[CH:10]=[CH:11]\[CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])C(=O)C2=CC=CC=C12>C(O)C.O>[NH2:8][CH2:9]/[CH:10]=[CH:11]\[CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
Hydrazine hydrate (0.19 ml) was added to a solution of (Z)-7-phtalimidohept-5-enoic acid (1.05 g) in ethanol (25 ml) and water (5 ml). The solution was refluxed for 3 hours and then the solvent was removed. The residue was suspended in water and the pH of the solution was adjusted to 5. The resulting precipitate was collected by filtration. The filtrate was evaporated to dryness and extracted with ethanol. The ethanol extracts were evaporated to dryness to give the title compound as an oil (0.62 g).
Workup
- temperatureThe solution was refluxed for 3 hours
- customthe solvent was removed
- filtrationThe resulting precipitate was collected by filtration
- customThe filtrate was evaporated to dryness
- extractionextracted with ethanol
- customThe ethanol extracts were evaporated to dryness
Sources & evidence
- ORD record
- ord-8e756c3c47864deebc89d4eb381cda53
- Source dataset
- uspto-grants-1991_03
- Patent number
- US04997847
Reaction notes
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